Angela C. Santomero is a television executive producer and co-creator of the long-running Nickelodeon children's television programs Blue's Clues, Super Why and Daniel Tiger's Neighborhood.

Santomero grew up in Harrington Park, New Jersey, where she graduated from Harrington Park Public School in 1982 before attending Northern Valley Regional High School at Old Tappan. She received her bachelor's degree from Catholic University, which later presented her with their Young Alumni Merit Award. She earned a master's degree in child development and psychology, with a specialty in instructional technology and media, from Columbia University. During graduate school, she was influenced by the research of Daniel R. Anderson, who studied the effects of television violence on children and later served as a researcher and consultant for Blue's Clues, and "became fascinated with the idea that if television could have a powerful negative effect on kids, it could have an equally powerful positive effect on them..." She was also influenced by Fred Rogers, host of Mister Rogers' Neighborhood and the researchers of Sesame Street.

Santomero worked as a researcher for Nickelodeon in the early 1990s, when the network was looking to create a new television show for preschoolers. In 1994, Santomero, along with director Todd Kessler and animator Traci Page Johnson, which Nickelodeon executive Brown Johnson called a "green creative team", created the "landmark" series Blue's Clues. According to writer Diane Tracy, Santomero, Kessler, and Johnson did not possess traditional backgrounds of most producers of children's programs, but "did possess an amazing combination of talents, backgrounds, and personal attributes". Santomero served as executive producer and head writer, and designed the show's research and curriculum. She produced and developed other Blue's Clues projects, such as the full-length movie Blue's Big Musical Movie, educational CDs and books based on the show, and two Blue's Clues theatrical productions, which toured across the U.S.

In 2007, Santomero created the PBS program Super Why!; she also served as executive producer and head writer. In 2011, she became host of PBS' The Parent Show, an online series about parenting. In September 2012, Daniel Tiger's Neighborhood, for which Santomero is executive producer and head writer, debuted on PBS.

Santomero resides in Greenwich, Connecticut, with her husband Greg, an Emmy Award-winning designer/creative director and their two daughters.